Migraine affects over a billion people, yet its cellular mechanisms remain unclear. This research studies how CGRP-blocking drugs interact with two key receptors—CGRP and AMY1—to understand why treatments help some patients but not others. The findings may guide development of more effective, targeted migraine therapies and reduce debilitating attacks.

My research uses spatial RNA sequencing to map where genes are expressed within tissues affected by chronic inflammatory diseases. By capturing genetic information with precise spatial coordinates, it creates an atlas of disease-driving genes. This deeper understanding may reveal new biomarkers and therapeutic targets, enabling future treatments beyond symptom management.

My research investigates tiny particles released by metastatic cancer cells—messengers that help cancer hide from the immune system. By capturing and analysing these particles, the study aims to uncover how they evade detection and to develop new strategies that “teach” the immune system to recognise and neutralise them, leading to safer, more effective cancer therapies.

This research searches for new antibiotics in deep-sea sponge bacteria that have evolved for 580 million years to defend their hosts. By growing these never-before-seen microbes and testing them against superbugs like MRSA, the project aims to discover urgently needed antibiotics to combat rising antimicrobial resistance.

The researcher rebuilds how cells sort materials to understand Alzheimer’s and Parkinson’s diseases. Using proteins and lipids like Lego pieces, they study how a key protein, retromer, malfunctions and disrupts cell transport. With cryogenic electron tomography, they aim to model this process and guide new treatments that restore healthy cellular function.