Re-Thinking Weed-Whacking: Overcoming ER+ Breast Cancer Therapy Resistance - Kelsi Gellatti

Year
2025
Organisation
University of Limerick
Tags
breast cancer
estrogen receptor positive
hormonal therapy resistance
SERDs
preclinical models
tumor microenvironment
adipose tissue
co-culture
single-cell RNA sequencing
drug development
Limerick
Summary

This research improves preclinical testing of SERDs (selective estrogen receptor degraders) for estrogen receptor–positive breast cancer by modeling the tumor environment and treatment resistance. By co-culturing cancer and fat cells and applying single-cell RNA sequencing, it identifies resistance mechanisms to support more effective drug development for patients.