After obtaining my Biochemistry BSc at UCL I joined the University of Bristol for the MRes with Dr Girish Mali as my supervisor. Here I had the task of elucidating the assembly of axonemal dynein which granted me the experience to acquire my current position on the Wellcome Trust Dynamic Molecular Cell Biology (4-year) PhD Programme in Prof Pete Cullen's lab. My project entails developing an in vitro reconstitution system of endosomal retrieval to dissect how multiprotein complexes interact with lipid membranes. This work may shed light on abnormalities observed in neurodegenerative diseases like Alzheimer's so needless to say I am very excited!
The researcher rebuilds how cells sort materials to understand Alzheimer’s and Parkinson’s diseases. Using proteins and lipids like Lego pieces, they study how a key protein, retromer, malfunctions and disrupts cell transport. With cryogenic electron tomography, they aim to model this process and guide new treatments that restore healthy cellular function.