This anthropological research investigates traditional medicinal uses of psilocybin mushrooms in Lesotho. Interviews with local healers revealed treatment practices that differ substantially from Western clinical models, including low-dose administration over extended periods and applications for epilepsy and psychosis. The findings may broaden future directions for psychedelic medicine research.

This research uses a validated rodent model of psychosis to study sensory-filtering deficits linked to schizophrenia. Instead of blocking dopamine D2 receptors, the study uses CDPPB to modulate mGlu5 receptors and reduce D2 hypersensitivity. Treatment restores normal sensory gating, suggesting a promising therapeutic pathway with fewer side effects than current antipsychotics.