This research improves the safety of stem cell–derived heart cell therapy for heart failure by engineering a drug-controlled genetic safety switch. The approach prevents dangerous post-transplant arrhythmias while allowing transplanted cells to mature and synchronize with the heart, advancing regenerative alternatives to full heart transplantation.

Heart failure causes major suffering, high mortality, and escalating healthcare costs. This research identifies what people with heart failure and their carers need from home-based supportive care, including nurse-led support, better communication, and coordinated services. By defining and prioritising key recommendations, the project aims to guide policy toward improving quality of life and reducing hospitalisations.