This research tests whether psychedelics improve adaptability in mice. After learning reward rules, mice with a single psychedelic treatment relearned new rules faster and used more information—learning not only from rewards but also from missed rewards. The findings suggest psychedelics enhance behavioral flexibility, offering clues for developing future mental health treatments.

Migraine affects over a billion people, yet its cellular mechanisms remain unclear. This research studies how CGRP-blocking drugs interact with two key receptors—CGRP and AMY1—to understand why treatments help some patients but not others. The findings may guide development of more effective, targeted migraine therapies and reduce debilitating attacks.