This research investigates Large Granular Lymphocyte Leukemia, where protective T cells become cancerous. The project explores how DNA methylation silences normal T-cell function and tests drugs that reverse this process. By removing harmful chemical modifications, the goal is to restore immune cells to their healthy, protective “superhero” role.

About 8% of the human genome originates from ancient viruses. This research uses bioinformatics and evolutionary comparisons to understand why viral DNA persists and how cells silence it through DNA methylation. Identifying how genomes separate useful from non-functional DNA helps clarify which genetic elements matter for human health and disease.

This research tests whether positive, therapy-induced epigenetic changes can be inherited. Using mice with genetic eye disease, the team applies a successful treatment, checks for vision improvement, examines resulting DNA chemical marks, and studies whether offspring inherit these beneficial modifications. Findings could reshape our understanding of therapy and generational health impact.