This thesis examines cytokine release storm, where the immune system becomes dangerously overactive. Using rat models, mathematical modelling, science and coding, she maps how corticosteroids move through organs and control inflammation. The goal is to optimise treatment for CRS during cancer therapy, COVID or future pandemics.

This research investigates Large Granular Lymphocyte Leukemia, where protective T cells become cancerous. The project explores how DNA methylation silences normal T-cell function and tests drugs that reverse this process. By removing harmful chemical modifications, the goal is to restore immune cells to their healthy, protective “superhero” role.

Researchers describe a simple strategy to slow Alzheimer’s disease by capping toxic tau protein chains. Inspired by a ring-stacking toy, they engineered spiky molecular “hats” that bind tau, halt aggregation, and reduce spread in cellular and postmortem brain models, suggesting broad potential across neurodegenerative disorders with future therapeutic promise worldwide.