IBD patients have weakened gut microbes, leaving them with chronic inflammation and limited treatment options. This research engineers probiotic yeast with anchors, drug-carrying “backpacks,” and reprogrammed DNA to deliver targeted therapeutics safely and cheaply. Early results show these modified microbes could become effective, low-side-effect treatments for IBD and other gut diseases.

Fruit flies normally die from sleep loss due to lethal gut inflammation. But a mutant “fumin” fly, which sleeps very little, survives without inflammation. This research investigates how altered dopamine processing protects these flies, offering insight into why sleep is essential and how sleep loss contributes to disease.