This research improves preclinical testing of SERDs (selective estrogen receptor degraders) for estrogen receptor–positive breast cancer by modeling the tumor environment and treatment resistance. By co-culturing cancer and fat cells and applying single-cell RNA sequencing, it identifies resistance mechanisms to support more effective drug development for patients.

PCBs, toxic “forever chemicals” found in older school buildings, accumulate in body fat and trigger harmful inflammation. This research shows that PCB-exposed fat cells recruit excessive immune cells, creating an uncontrolled inflammatory response that contributes to obesity and diabetes. Understanding this mechanism opens pathways for treatments targeting fat–immune cell communication.