This research investigates why blocking an early asthma “alarmin” signal often fails as a treatment. Using mouse models, it reveals that environmental differences—particularly the microbiome—can bypass this signal and still drive asthma. Understanding microbiome health may help predict treatment success and lead to more personalized, effective asthma therapies.

This research explores how gut bacteria communicate with the brain to regulate appetite. Using zebrafish, it shows that dietary fiber supports microbiome diversity, producing signals that suppress hunger. Disrupted gut–brain communication from low-fiber diets may drive overeating, highlighting new targets for obesity prevention.