This thesis developed multifunctional 3D-printed scaffolds for repairing critical-size mandibular bone defects. Using bioactive ceramics, surface coatings, and prevascularization strategies, it promoted both osteogenesis and angiogenesis. Results show that combining geometry, materials, and biological signals enables synergistic tissue regeneration, offering less-invasive alternatives to autologous bone grafts.

This research engineers immune T cells to better fight ovarian cancer. By modifying them to recognize tumor-specific proteins and resist cancer’s suppressive signals, the project strengthens the body’s natural defenses. The goal is to improve immunotherapy effectiveness, overcome tumor resistance, and increase survival rates for women facing this deadly disease.

This research investigates why blocking an early asthma “alarmin” signal often fails as a treatment. Using mouse models, it reveals that environmental differences—particularly the microbiome—can bypass this signal and still drive asthma. Understanding microbiome health may help predict treatment success and lead to more personalized, effective asthma therapies.

This research investigates why women are more vulnerable to stress-related disorders. Using a mouse model of acute trauma, the study shows that estrogen levels in the hippocampus drive memory disruption after stress. Blocking local estrogen production protects memory, revealing sex-specific mechanisms relevant for targeted treatments.

This talk highlights the importance of science communication. Despite the fear of public speaking, sharing research can directly impact lives. A three-minute research presentation led to a pediatric cancer patient receiving treatment, demonstrating how communicating science beyond the lab can translate into real-world benefits.

Type 1 diabetes affects millions worldwide and often begins in childhood, with no cure or prevention. This research uses early-life blood samples and single-cell immune profiling to identify genetic changes in immune cells before disease onset. The findings reveal new biomarkers that could enable early detection, targeted therapies, and future disease prevention.

This research targets muscle stiffness in children with cerebral palsy by breaking down excess collagen in the muscle’s extracellular matrix. Treating muscle tissue with collagenase reduced stiffness by 50% without weakening muscle strength. The findings offer a promising step toward therapies that improve mobility, reduce pain, and enhance quality of life.

This research links two major treatment challenges in childhood acute lymphoblastic leukemia through ferroptosis, a lipid oxidation process regulated by selenium. By targeting selenium uptake in the brain and after chemotherapy, the work identifies potential new therapeutic strategies to reduce cancer cell survival and improve long-term treatment outcomes.

Respiratory Syncytial Virus (RSV) hospitalises thousands of children each year, yet effective treatments remain unavailable. This research investigates a critical protein–protein interaction that enables RSV infection. By identifying and disrupting key molecular binding sites using AI, the work aims to support the development of targeted antiviral therapies for severe RSV.

This research develops a rapid, light-based method to study viral fusion, the first step of infection. By applying split NanoLuc technology to HIV, it reveals strain-specific fusion behaviors and unexpected regulatory steps, providing tools that can accelerate responses to future pandemics such as COVID-19.