This thesis investigates how gut microbes influence brain health through short-chain fatty acids produced from dietary fibre. Measuring these compounds in stool samples, the research finds lower levels in people at risk for Alzheimer’s disease. The next phase tests whether supplementing short-chain fatty acids can prevent or treat Alzheimer’s in mouse models.

This research explores how gut bacteria communicate with the brain to regulate appetite. Using zebrafish, it shows that dietary fiber supports microbiome diversity, producing signals that suppress hunger. Disrupted gut–brain communication from low-fiber diets may drive overeating, highlighting new targets for obesity prevention.