This thesis investigates how gut microbes influence brain health through short-chain fatty acids produced from dietary fibre. Measuring these compounds in stool samples, the research finds lower levels in people at risk for Alzheimer’s disease. The next phase tests whether supplementing short-chain fatty acids can prevent or treat Alzheimer’s in mouse models.

This research investigates how the infant gut microbiota influences childhood asthma risk. By studying microbes from infant diapers, the project identifies protective and harmful bacteria, explores the effects of genetics and environmental exposures, and highlights opportunities for early intervention and probiotic-based prevention. Understanding gut–immune interactions may transform childhood asthma prevention.