This research develops nanoscale “smart package” delivery systems for PROTAC cancer drugs. Antibody nanogel conjugates selectively target cancer cells, enter them, and release therapeutic molecules while minimizing exposure to healthy tissue. The approach improves delivery efficiency and aims to reduce the severe side effects that often limit cancer treatment.

The talk explains how drug discovery struggles with the enormous size of chemical space, where only a few molecules become effective medicines. Using miniaturized chemical libraries and off-rate screening, the researcher accelerates structure–activity relationships (SAR) mapping without purification. This approach has already produced promising breast-cancer drug candidates and could dramatically reduce drug-development costs.

This research searches for new antibiotics in deep-sea sponge bacteria that have evolved for 580 million years to defend their hosts. By growing these never-before-seen microbes and testing them against superbugs like MRSA, the project aims to discover urgently needed antibiotics to combat rising antimicrobial resistance.