Migraine affects over 10% of people and disproportionately impacts women. This research studies sex differences in brain circuits using mouse models to understand why. By manipulating neural pathways, findings show certain circuits trigger migraine-like sensitivity only in females. Mapping these circuits may enable personalized, more effective migraine treatments.

This research uses advanced brain imaging, long-term clinical monitoring, and sensor data to understand why deep brain stimulation helps Essential Tremor patients—and why it sometimes stops working. By modelling neural pathways and analysing two-year outcomes, the project identifies optimal DBS targets and the main causes of treatment failure, improving long-term patient care.

This research tests a new personalised care model for Parkinson’s called Prime Care, offering rapid access to support and tailored interventions based on each patient’s risk of hospital admission. A two-year clinical trial of 214 participants will determine whether this approach improves wellbeing and reduces costly, harmful hospital stays.