Healing depends on a balance between extracellular matrix stiffness and cellular recycling through autophagy. This research shows that disrupted balance leads to chronic wounds or fibrotic scarring. By engineering materials with tunable stiffness, the work reveals how cells “sense” their environment, opening new paths to guide healthier wound healing.

The speaker investigates why surgical sutures often fail and explores bio-inspired alternatives. Studying freshwater mussels—experts at sticking to wet surfaces—they analyze adhesive proteins to design stronger, water-compatible tissue adhesives. This research aims to create safer, more reliable surgical closure methods that reduce complications, infections, and reliance on traditional suturing.