Intestinal cells protect us from harmful bacteria by forming a physical barrier and raising immune danger signals when needed. This research reveals a nuclear “knight” molecule that suppresses unnecessary immune activation during metabolic stress, helping maintain intestinal health and preventing excessive inflammation.

Adolescent depression is common, severe, and highly recurrent, with risk increasing after each episode. This research studies why some young people relapse while others recover, examining biological stress responses, coping styles, social relationships, and lived experience. The goal is to develop interventions that strengthen long-term resilience and improve mental-health outcomes.