Prion diseases like CJD are extremely hard to detect early because harmful prions resemble normal brain proteins. This research introduces a new “flashbody” detection tool that binds only disease-causing prions, providing rapid, accurate, equipment-free diagnosis. Early lab results and patient-screening trials are promising, with potential applications to Alzheimer’s and other dementias.

This research develops one of the most advanced human-engineered brain models to better study Alzheimer’s disease and test treatments. Using microfluidic chips containing all key brain cell types, blood-vessel systems, and Alzheimer’s-model neurons, the project enables efficient drug testing, personalised disease modelling, and the possibility of replacing animal testing in the search for a cure.

This research investigates how T cells influence microglial behavior in Alzheimer’s disease. Using a mouse model, the study found that removing T cells did not alter amyloid-beta plaques but unexpectedly led to healthier microglial activity and reduced myelin damage. The findings suggest T cells may worsen neurodegeneration and reveal new therapeutic avenues.

Umami, the savory fifth taste, can significantly increase saliva production and stimulate the swallowing reflex, offering potential benefits for people with dysphagia. In a study of 70 participants, foods high in umami boosted salivation, swallowing ease, and enjoyment. This research highlights umami’s promise for improving safety and pleasure in eating.

The researcher rebuilds how cells sort materials to understand Alzheimer’s and Parkinson’s diseases. Using proteins and lipids like Lego pieces, they study how a key protein, retromer, malfunctions and disrupts cell transport. With cryogenic electron tomography, they aim to model this process and guide new treatments that restore healthy cellular function.