This research designs simplified, custom-built proteins to understand how natural proteins work and to create new biocatalysts. By choosing a desired function and designing the amino-acid sequence and structure from scratch, the project aims to develop clean, efficient protein-based alternatives to environmentally harmful industrial chemistry.

The researcher rebuilds how cells sort materials to understand Alzheimer’s and Parkinson’s diseases. Using proteins and lipids like Lego pieces, they study how a key protein, retromer, malfunctions and disrupts cell transport. With cryogenic electron tomography, they aim to model this process and guide new treatments that restore healthy cellular function.