Using a Twilight analogy, this research explains antibiotic-resistant bacteria as “vampires” protected by membranes. By crystallizing membrane proteins and analyzing them with X-ray techniques, the study reveals their structure and function. This enables precise drug design to block these proteins, potentially overcoming antibiotic resistance and targeting harmful bacteria more effectively.

This research designs simplified, custom-built proteins to understand how natural proteins work and to create new biocatalysts. By choosing a desired function and designing the amino-acid sequence and structure from scratch, the project aims to develop clean, efficient protein-based alternatives to environmentally harmful industrial chemistry.

The researcher rebuilds how cells sort materials to understand Alzheimer’s and Parkinson’s diseases. Using proteins and lipids like Lego pieces, they study how a key protein, retromer, malfunctions and disrupts cell transport. With cryogenic electron tomography, they aim to model this process and guide new treatments that restore healthy cellular function.