This study introduces a “brain stress test” for depression, combining targeted brain stimulation with neuroimaging. Depressed individuals show exaggerated brain responses, which increase with repeated episodes. The test may serve as an early warning signal, helping clinicians identify relapse risk and intervene before depression returns.

This research investigates transcranial electrical stimulation (tACS) as a non-invasive way to modulate prefrontal cortex activity in people with severe mental disorders such as schizophrenia. By measuring brain activity, cognition, and behavior, the study aims to identify conditions where tACS is effective and offer a safe, accessible therapeutic alternative.