This research investigates Large Granular Lymphocyte Leukemia, where protective T cells become cancerous. The project explores how DNA methylation silences normal T-cell function and tests drugs that reverse this process. By removing harmful chemical modifications, the goal is to restore immune cells to their healthy, protective “superhero” role.

This research develops a computational method for detecting hidden RNA viruses within existing RNA sequencing datasets. By identifying conserved viral protein signatures, the approach enables large-scale discovery of previously unknown viruses, improving understanding of viral diversity, disease mechanisms, and future opportunities for diagnostics, surveillance, and antiviral treatment development.

Type 1 diabetes destroys insulin-producing cells, leaving patients dependent on lifelong injections. Islet transplants could provide freedom, but most cells die quickly. This research uses drug-loaded microparticles that protect transplanted islets, boosting survival, insulin production, and diabetes reversal. The approach could cut costs, reduce donor needs, and transform treatment for multiple diseases.